The Wrestler (2008)
Aronofsky's 2008 professional wrestling drama. Aging body as central content.
Marisa Tomei won Best Supporting Actress for My Cousin Vinny, and a persistent rumour that the presenter read the wrong name circulated for years despite being entirely false. It followed her for a decade.
The performance deserves it. Mona Lisa Vito is a comic role that requires precise technical delivery, and the testimony scene is a masterclass.
She was nominated twice more, for In the Bedroom and The Wrestler, both serious dramatic work in a completely different register.
She then became Aunt May across the Spider-Man films, playing the character considerably younger than any previous version, which the films use as a joke and she plays straight.