Requiem for a Dream (2000)
Aronofsky's 2000 addiction film. Four people destroyed in parallel tracks.
Jennifer Connelly began at eleven in Once Upon a Time in America and was in Labyrinth at fifteen opposite David Bowie, which is the film most audiences met her through.
She won Best Supporting Actress for A Beautiful Mind, playing a woman married to a man whose illness makes him unreachable, and the performance is largely reactive by design.
Requiem for a Dream is the harder watch and the better work, and she has said the shoot was among the most difficult of her career.
Dark City, House of Sand and Fog and Top Gun: Maverick fill out an unusually varied filmography for someone who started that young.