The Killers (1946)
Robert Siodmak's 1946 Hemingway adaptation. The murder happens in the first ten minutes.
Edmond O’Brien won Best Supporting Actor for The Barefoot Contessa, playing a press agent who perspires continuously, which became something of a signature.
D.O.A. gives him the premise every noir wishes it had: a man walks into a police station to report his own murder, having been poisoned with a slow-acting toxin.
The Killers, White Heat and The Wild Bunch fill out a long career, and he was also nominated for Seven Days in May.