Hayao Miyazaki co-founded Studio Ghibli and has drawn key frames himself well into his eighties, refusing most of the digital shortcuts the industry adopted. The insistence is not nostalgia, it is a claim about what hand-drawn movement can do that interpolation cannot.
His films frequently have no villain. My Neighbour Totoro contains no antagonist at all, and Princess Mononoke gives its apparent one a coherent argument. The recurring subjects are flight, environmental damage, and girls who solve problems through competence instead of rescue.
Spirited Away won the Academy Award for Best Animated Feature and remains the only hand-drawn non-English film to do so. He has announced his retirement several times and returned each time.