And Then There Were None (1945)
Rene Clair's 1945 Agatha Christie adaptation. The template for every isolation murder mystery since.
Walter Huston won Best Supporting Actor for The Treasure of the Sierra Madre, directed by his son John, who won Best Director for the same film. It remains the only father and son to win in the same year.
His performance as the old prospector Howard is built on physical energy that outpaces men half his age, including a dance he performs on being proven right about the gold.
Dodsworth and The Devil and Daniel Webster are the earlier work. His grandson Danny and granddaughter Anjelica both continued the family in film.