Shadow of the Vampire (2000)
What if the actor in Nosferatu was a real vampire? The conceit is irresistible.
John Malkovich was nominated twice, for Places in the Heart and In the Line of Fire, the second playing an assassin whose calm is the entire threat. Being John Malkovich required him to play a fictionalised version of himself being inhabited by strangers. He co-founded Steppenwolf in Chicago and works constantly in European film.