Karen Allen played Marion Ravenwood in Raiders of the Lost Ark, and the character is the only romantic lead in that series who is a genuine match for Indiana Jones instead of a passenger. The drinking contest establishes it in ninety seconds.
Animal House and Starman filled the same period, the latter opposite Jeff Bridges in a performance of considerable warmth.
She largely left Hollywood in the 1990s, running a textile business in Massachusetts and teaching, and returned for two later Indiana Jones films.
She has directed and works regularly in theatre, and has been candid that the decision to step away was deliberate.